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Leptin in leanness and obesity: JACC state-of-the-art review

2527 In patients with MELAS, they have defective oxidative phosphorylation mechanisms

Current status Ozempic : FDA approved for adults with type 2 diabetes Wegovy : semaglutide product FDA approved for chronic weight management in eligible patients Retatrutide : not FDA approved as of March 25, 2026 FDA has also warned consumers about illegally sold unapproved GLP-1-related products containing retatrutide